Question

163. To achieve complete separation of two phamaceutical compounds (shown as two peaks in the chromatogram), the relative separation (Rs) should be UV 2(VR2 -VR1) Volume VR1 VR2 Wo2 a. 1 b. 2 1.5 C. < 0.5 d. 0.8

1. Please explain the concept of chromatographic separation and formulas in the above question.

2) If a big centrifuge with the bowl diameter of 1m rotates at 60 rpm, at what speed (rpm) does a smaller centrifuge with a diameter of 0.5 m need to be operated for achieving the same separation factor?
(a) 85
(b) 120
(c) 30
(d) 42

3) What is the linear flow rate (superficial velocity in cm/h) in a chromatographic column of 1.0 cm inner diameter with a bed porosity of 0.8 when the volumetric flow rate is 1 ml/min?
a) 61.1
b) 76.4
c) 38.2
d) 15.2

Answer 1

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