Question

Nitrogen nucleophiles have different outcomes in reactions with aldehydes and ketones, after formation of the tetrahedral intermediate and depending on the type of nucleophile (1^o, 2^o or 3^o).

Provide the products formed by the reaction of acetaldehyde and 2-butanone with the following nitrogen nucleophiles.

            a.

,H t, pH 4-5

            b.

            c.

            d.

Answer 1

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