Question

An important step in the blood coagulation process is the enzymatic conversion of the protein prothrombin to the lower-molecular-weight clotting agent, thrombin, via cleavage of a portion of the prothrombin polypeptide. Prothrombin → thrombin + cleaved peptide

The values of s20,w and D20,w for prothrombin have been found to be 4.85S and 4.93×10^−11 m2s−1 , respectively.

The diffusion coefficient for thrombin is 8.76×10^−11 m2s−1. Assuming that both thrombin and prothrombin are unhydrated spheres with vB=0.70ml g−1, calculate the molecular weight of the cleaved peptide. [Express your answer in units of kg/mol]

Answer 1

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