Question

certain drugs are commonly used to study mitochondrial respiration. These drugs include Rotenone, oligomycin, and the...

certain drugs are commonly used to study mitochondrial respiration. These drugs include Rotenone, oligomycin, and the mitochondrial uncoupler dinitrophenol. Rotenone inhibits the transfer of electrons from Complex 1 to Uniquinone, oligomycin inhibits Complex 5/ATP synthase by preventing the re-entry of protons into the matrix, and Dinitrophenol leads to the uncoupling of oxidation from phosphorylation of ADP (meaning that less ATP is produced). If you were interested in studying the ATP production through glycolysis only, which of these inhibitors would be most useful? Why?
0 0
Add a comment Improve this question Transcribed image text
Answer #1

Answer:

Drugs mentioned in question are categorised as follows:

  • Electron transport inhibitors
    • Rotenone
    • Antimycin
    • Cyanide
    • Malonate (succinate dehydrogenase inhibitor)
  • Uncoupling agents
    • 2,4-Dinitrophenol (DNP)
    • Carbonyl cyanide p-[trifluoromethoxy]-phenyl-hydrazone (FCCP)
  • Oligomycin (inhibitor of oxidative phosphorylation)

These are not inhibitors of the glycolysis

Add a comment
Know the answer?
Add Answer to:
certain drugs are commonly used to study mitochondrial respiration. These drugs include Rotenone, oligomycin, and the...
Your Answer:

Post as a guest

Your Name:

What's your source?

Earn Coins

Coins can be redeemed for fabulous gifts.

Not the answer you're looking for? Ask your own homework help question. Our experts will answer your question WITHIN MINUTES for Free.
Similar Homework Help Questions
  • Inhibitors of Oxidative Phosphorylation The following chemicals inhibit oxidative phosphorylation: Cyanide: Cyanide is a naturally occurring...

    Inhibitors of Oxidative Phosphorylation The following chemicals inhibit oxidative phosphorylation: Cyanide: Cyanide is a naturally occurring compound that binds to protein complex IV of the mitochondrial electron transport chain and prevents transfer of electrons from the protein. Metformin: At the cellular level, chemically synthesized metformin, a drug commonly prescribed for Type 2 diabetes, inhibits mitochondrial respiration by blocking complex I. Dinitrophenol: Dinitrophenol is a metabolic poison that can be sold legally as a pesticide. Although it is lethal to humans,...

  • Inhibitors of Oxidative Phosphorylation The following chemicals inhibit oxidative phosphorylation: Cyanide: Cyanide is a naturally occurring...

    Inhibitors of Oxidative Phosphorylation The following chemicals inhibit oxidative phosphorylation: Cyanide: Cyanide is a naturally occurring compound that binds to protein complex IV of the mitochondrial electron transport chain and prevents transfer of electrons from the protein. Metformin: At the cellular level, chemically synthesized metformin, a drug commonly prescribed for Type 2 diabetes, inhibits mitochondrial respiration by blocking complex I. Dinitrophenol: Dinitrophenol is a metabolic poison that can be sold legally as a pesticide. Although it is lethal to humans,...

  • QUESTION 1 Which of the following options lists the stages in cellular respiration in the correct...

    QUESTION 1 Which of the following options lists the stages in cellular respiration in the correct order? A. glycolysis, oxidative phosphorylation, pyruvate oxidation, and the citric acid cycle B glycolysis, pyruvate oxidation, the citric acid cycle, and oxidative phosphorylation C. pyruvate oxidation, oxidative phosphorylation, glycolysis, and the citric acid cycle D. the citric acid cycle, oxidative phosphorylation, pyruvate oxidation, and glycolysis QUESTION 2 When a glucose molecule loses a hydrogen atom as the result of an oxidation-reduction reaction, the glucose...

  • Please explain why as well. 4. On average, how many ATP molecules are synthesized per NADH?...

    Please explain why as well. 4. On average, how many ATP molecules are synthesized per NADH? A. 0 B. 1 C. 2 D. 3 E. 4 5. The FADH2 that is produced donates its electrons directly to A. Complex I B. Complex III C. Complex IV D. Coenzyme Q E. Cytochrome C F. O2 6. In the Binding Change Mechanism the 3 conformational states that occur in the F1 subunit of ATP synthase depend on A. interaction with b subunits...

  • 14. The molecule 2,4-dinitrophenol (DNP) is an uncoupling agent that breaks down the concentration gradient of...

    14. The molecule 2,4-dinitrophenol (DNP) is an uncoupling agent that breaks down the concentration gradient of protons formed during oxidative phosphorylation. DNP shuttling protons across the cell membrane, equalizing the concentration of protons on either side of the membrane. Which of the following will be true for a bacterium poisoned with DNP? a. The cell will have an increased level of NADH in the cytoplasm b. Oxygen will not be converted to water by the electron transport chain c. Glycolysis...

  • 14. The molecule 2,4-dinitrophenol (DNP) is an uncoupling agent that breaks down the concentration gradient of...

    14. The molecule 2,4-dinitrophenol (DNP) is an uncoupling agent that breaks down the concentration gradient of protons formed during oxidative phosphorylation. DNP shuttling protons across the cell membrane, equalizing the concentration of protons on either side of the membrane. Which of the following will be true for a bacterium poisoned with DNP? a. The cell will have an increased level of NADH in the cytoplasm b. Oxygen will not be converted to water by the electron transport chain c. Glycolysis...

  • Q2. The release of ATP by the beta subunit is most directly dependent on: Select ONE...

    Q2. The release of ATP by the beta subunit is most directly dependent on: Select ONE option: 1. the flow of protons from the intermembrane space to the matrix. 2. the rotation of the c-ring in the membrane. 3. the passage of electrons along the electron transport chain. 4. a conformational change in the beta subunit. Q3. What defines the direction of rotation of the c-ring in the F0 complex? (Select ALL that apply.) 1. Amino acids side chains in...

  • I'd like to ask the answers for all of the uestions Question 1. A reaction in...

    I'd like to ask the answers for all of the uestions Question 1. A reaction in an anabolic pathway in a cell has a AG of +2.5 kcal/mol. Which of the following is true regarding this reaction? A. It will occur spontaneously. B. The product of the reaction has a lower free energy than the reactants. C. It can occur if it is coupled to ATP hydrolysis. D. It is an exergonic reaction. E. It is breaking a polymer into...

  • 1. According to the paper, what does lactate dehydrogenase (LDH) do and what does it allow...

    1. According to the paper, what does lactate dehydrogenase (LDH) do and what does it allow to happen within the myofiber? (5 points) 2. According to the paper, what is the major disadvantage of relying on glycolysis during high-intensity exercise? (5 points) 3. Using Figure 1 in the paper, briefly describe the different sources of ATP production at 50% versus 90% AND explain whether you believe this depiction of ATP production applies to a Type IIX myofiber in a human....

ADVERTISEMENT
Free Homework Help App
Download From Google Play
Scan Your Homework
to Get Instant Free Answers
Need Online Homework Help?
Ask a Question
Get Answers For Free
Most questions answered within 3 hours.
ADVERTISEMENT
ADVERTISEMENT
ADVERTISEMENT