Notch / Jagged (Delta) Pathway
Highly conserved cell signaling system present in most multicellular organisms; |
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Controls multiple cell differentiation processes during embryonic and adult life; |
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Notch signaling is disregulated in many cancers and other diseases including T-ALL (T-cell acute lymphoblastic leukemia), CADASIL (Cerebral Autosomal Dominant Arteriopathy with Sub-cortical Infarcts and Leukoencephalopathy), MS (Multiple Sclerosis) and myriad other disease states. |
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Highly conserved cell signaling system present in only animal cells |
The Notch signaling pathway is a highly conserved cell signaling system present in most multicellular organisms.
It controls multiple cell differentiation processes during embryonic and adult life.
Notch signaling is dysregulated in many cancers, and faulty notch signaling is implicated in many diseases including CADASIL (Cerebral Autosomal Dominant Arteriopathy with Sub-cortical Infarcts and Leukoencephalopathy), T-ALL (T-cell acute lymphoblastic leukemia), Alagille syndrome, MS (Multiple Sclerosis), and myriad other disease states.
The Notch signaling pathway is a highly conserved cell signaling system present in most animals.
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Notch / Jagged (Delta) Pathway Highly conserved cell signaling system present in most multicellular organisms; Controls...