Give the Mechanism for this reaction
6. complete the following reactions. a) 1. heat 2. H2O Br KOH Toluene b) Pd(OAc)2 Pd(o-tolyl)3 Et3N, 100°C acetonitrile O Br
Could you please draw a mechanism for the above reaction
Pd(OAc)2 TBAB K2CO3 . + H0 محBr V TOME Me0 5-phenyl-2-hydroxyacetophenone
2. Referencing the following reactions: H20 NaOH Pd/C H O NHA MeOH, reflux a, Predict a product for the hydrogenation of the chalcone (1pt) b, Calculate the atom economy for each reaction. (3 pts) c. Calculate the E-factor for each reaction. (2 pts) d. Based on the syntheses and green parameters calculated above, comment on the overall greenness of the synthesis. (2 pts)
o Heck reaction RCH CH2 CI Pd Fill in mechanism below:
o Heck reaction RCH CH2 CI Pd Fill in mechanism below:
5. Draw the structure of the product formed of each reaction. Br + Pd(PPhy) NaOH Br + Pd(PPh 4 NaOH Pd(PPh34 NaOH -Br + H2C=CH2 Pd(OAC)2 PPh3, Et3N Hzco CH3CH2CH2CH2CH2-Br + Culi Qafarov —
draw the full mechanism for the reaction.
m. so Et3N CC14
(b) The terpyridine ligand 9 can be made using Pd(0) catalyzed cross-coupling reaction. 8 (2 eq.) Sn(Bu)3 Pd(PPhz)4 (cat.), toluene, reflux Br N Br (i) Provide a mechanism for the Pd(0) catalyzed cross-coupling reaction between 7 and 8 that details the complete catalytic cycle for a single substitution process.
00 Pd(OAC)2 OH P(t-Bu)2(biphen) K₃PO4 CH3 toluene, 100 °C OCH3 (dppf)PdCl2 КОАс DMSO 80 °C CF3 Cyg CluRua CI, c. Acor CI PC Ph CH2Cl2, 40 °C Pd(OAC)2 Plo-Tol), MeCN NEtz, 80 °C
provide the reaction mechanism for the formation kf the product
using the reagents listed
Pd (PPh 3) u Nu, coz toluene / Me OH (2:1) reflux
18. Give the curved arrow mechanism for each reaction. KOH, H2O KOH,H,O O NaOH,H,O 0028