What happens to the double bonds during the cyclization of squalene epoxide during cholesterol synthesis?
What happens to the double bonds during the cyclization of squalene epoxide during cholesterol synthesis?
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What happens to the double bonds during the cyclization of
squalene epoxide during cholesterol synthesis?
Statins work to inhibit cholesterol synthesis by competing for the active site of an enzyme involved...
Statins work to inhibit cholesterol synthesis by competing for the active site of an enzyme involved in this pathway. What is the normal product of this enzyme? a. Squalene b. Mevalonate c. HMG CoA d. Isopenetnyl pyrophosphate
Experiment Questions What is an epoxide and how is it useful with respect to synthesis design?...
Experiment Questions What is an epoxide and how is it useful with respect to synthesis design? • What are typical reagents used for epoxidation? • What is the mechanism for epoxidation? Must stereospecificity be considered? Experiment Techniques • Use of sodium bisulfite wash to remove excess peroxy acid from reaction mixture. Introduction By now you are well aware that the product of previous experiment (reaction of cyclohexanol and acid) is an alkene. You should also be storing key reactions of...
Question #8 (10 points) - During fasting, explain what happens for carbohydrate metabolism (glycogen synthesis/breakdown; glucose...
Question #8 (10 points) - During fasting, explain what happens for carbohydrate metabolism (glycogen synthesis/breakdown; glucose synthesis/breakdown/insulin & glucagon levels)
2) Which statement is NOT true? A) Cholesterol is a prominent member of the steroid family....
2) Which statement is NOT true? A) Cholesterol is a prominent member of the steroid family. B) Cholesterol is insoluble in the aqueous medium of the blood. C) Cholesterol serves as the starting material for the synthesis of all other steroids. D) Cholesterol is a vital component for healthy cell membranes. E) Cholesterol cannot be synthesized in the body, and therefore is required in the diet. 3) Which of the following statements is NOT true regarding lipids? A. Lipids come...
#59) During protein synthesis, what happens to the ribosome? A) attach to the mRNA molecule and...
#59) During protein synthesis, what happens to the ribosome? A) attach to the mRNA molecule and travel along its length B) attach to the DNA molecule and travel along its length to produce an mRNA molecule C) Translate mRNA into tRNA D) Transcribe mRNA to tRNA E) Translate mRNA into DNA #60) if you digested the human genome (3 billion bp) with a 7-cutter restriction enzyme, approximately how many fragments would you get? A) 511461 B)183105 C)16384 D)88 E) None...
Rachel is studying cholesterol synthesis in mice. Some mice had a mutation in their sterol regulatory...
Rachel is studying cholesterol synthesis in mice. Some mice had a mutation in their sterol regulatory element binding protein (SREBP) that is normally active when cholesterol levels are low in the cell. This mutation can no longer bind to the gene promoter for cholesterol synthesis pathway enzyme HMG-CoA reductase. What would happen to HMG-CoA reductase levels? Again, identify this type of effect and briefly define it.
1- Which of the following statements about cholesterol regulation is false? A) Insulin stimulates the production...
1- Which of the following statements about cholesterol regulation is false? A) Insulin stimulates the production of cholesterol. B) High intracellular cholesterol levels stimulate proteolysis of HMG-CoA reductase. C) High intracellular cholesterol levels inhibit the uptake of extracellular cholesterol. D) Glucagon stimulates the production of cholesterol. 2- Which statement is incorrect about the synthesis of fatty acids by fatty acid synthase in mammals? A) It uses FADH2 as a reductant of carbon-carbon double bonds. B) It uses NADPH as a...
5. Robinson used his annulation reaction in the total synthesis of cholesterol that he published in...
5. Robinson used his annulation reaction in the total synthesis of cholesterol that he published in 1951. (His interest in the synthesis dated back to 1932!) The synthesis was very important for the synthesis of other steroids. Describe in words what is changing from reactants to products in each step and provide the reagents necessary for each conversion. MeMe Me. SH HO Cholesterol (a steroid!) The number of stereoisomers of a molecule can be predicted (in most cases) by using...
Part 1) If you double the current in the wire, what happens to the force on...
Part 1) If you double the current in the wire, what happens to
the force on the wire? What about the force on the magnet?
Part 2) If you double the length of the wire, what happens to
the force on the wire? What about the force on the magnet?
Part 3) If you double the magnetic field that the wire is in,
what happens to the force on the wire? What about the force on the
magnet?
A current-carrying...
What happens to the surface area when you double the size of the cell (1 cm...
What happens to the surface area when you double the size of the cell (1 cm to 2 cm cell)? (2 points) What happens to the volume when you double the size of the cell (1 cm to 2 cm cell)? (2 points)
Experiment Questions What is an epoxide and how is it useful with respect to synthesis design? • What are typical reagents used for epoxidation? • What is the mechanism for epoxidation? Must stereospecificity be considered? Experiment Techniques • Use of sodium bisulfite wash to remove excess peroxy acid from reaction mixture. Introduction By now you are well aware that the product of previous experiment (reaction of cyclohexanol and acid) is an alkene. You should also be storing key reactions of...
Question #8 (10 points) - During fasting, explain what happens for carbohydrate metabolism (glycogen synthesis/breakdown; glucose synthesis/breakdown/insulin & glucagon levels)
2) Which statement is NOT true? A) Cholesterol is a prominent member of the steroid family. B) Cholesterol is insoluble in the aqueous medium of the blood. C) Cholesterol serves as the starting material for the synthesis of all other steroids. D) Cholesterol is a vital component for healthy cell membranes. E) Cholesterol cannot be synthesized in the body, and therefore is required in the diet. 3) Which of the following statements is NOT true regarding lipids? A. Lipids come...
5. Robinson used his annulation reaction in the total synthesis of cholesterol that he published in 1951. (His interest in the synthesis dated back to 1932!) The synthesis was very important for the synthesis of other steroids. Describe in words what is changing from reactants to products in each step and provide the reagents necessary for each conversion. MeMe Me. SH HO Cholesterol (a steroid!) The number of stereoisomers of a molecule can be predicted (in most cases) by using...
Part 1) If you double the current in the wire, what happens to
the force on the wire? What about the force on the magnet?
Part 2) If you double the length of the wire, what happens to
the force on the wire? What about the force on the magnet?
Part 3) If you double the magnetic field that the wire is in,
what happens to the force on the wire? What about the force on the
magnet?
A current-carrying...
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