Question

If pyruvate labeled with 14C in the 1 position were metabolized under aerobic conditions by mammalian cells, what compound would be labeled in what position? OA. CO2 B. C-1 of ethanol CC-2 of acetate D.C-2 of citrate E. C-1 of oxaloacetate F. none of the above.

Answer 1

NADH SCOA NAO со C3 14 CH3 -CO2 coenzyme A under aerobic cenditors, presence of onegen percevate gives the acetyl con Acelyl COA with oxaloacetate enters to the citric acid yde to give eitrate. Oxelbacetale reacts with acetyl coa and H₂O to yield citrate and CoA. Its an absol condensation reaction followed by hydrolysis which is catalysed by citrate synthare catry CoA foomed and hydrolyse to citrate and coA. HSCOA COA e) 14CH 140 labelled acetyl GOA 22 no CCC t СИ. CH2 occo exaloare todo (citrate finally Aus enters part to d of ce toate. the 62 stuchere of citite en