Question

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Complete the reaction for the biosynthesis of thymidine monophosphate (dTMP) from the substrate and the coenzyme N5,N10 -methylenetetrahydrofolate (5,10-methylene-THF). Note: Not all terms will be used. + 5,10-Methylene-THF rightarrow dTMP + dCMP Select the three true statements. The sole purpose of 5,10-methylene-THF is to donate hydrogen atoms. 5,10-methylene-THF must be regenerated from DHF in order to continue to produce dTMP. The enzyme that catalyzes this reaction is a target for the treatment of cancer. This reaction is part of all three salvage synthesis pathways of dTTP. This reaction is catalyzed by thymidylate synthase.

Answer 1

dUMP + 5,10-Methylene-THF→ dTMP + dihydrofolate

The sole purpose of 5,10-methylene-THF is to donate hydrogen atoms. Br-methylene-THF must be regenerated from DHF in order to continue to produce dTMP. gf he enzyme that catalyzes this reaction is a target for the treatment of cancer. This reaction is part of all three salvage synthesis pathways of dTTP This reaction is catalyzed by thymidylate synthase.