When performing a Friedel-Crafts alkylation reaction, not only does one have the problems of multiple alkylation...
Friedel-Crafts Acylation of Ferrocene "riedel-Crafts reactions are examples of electrophilic aromatic substitution reactions. The eaction involves the substitution of hydrogen on the aromatic ring system by an electrophilic arbon species forming a new carbon-carbon bond. Friedel-Crafts reactions may be used to ntroduce either an alkyl or acyl group. Ferrocene does not undergo addition reactions typical of cyclopentadiene, but undergoes Electrophilic aromatic substitution. The Friedel-Crafts acylation reaction of ferrocene involves he addition of the acylium cation to one of the carbon...
Friedel-Crafts Acylation of Ferrocene H3PO4 DISCUSSION 1. This reaction is done with a 10-fold excess of acetic anhydride, yet the dominant product of the reaction is the mono-acylated compound. Very little 1,1'-diacetylferrocene is formed. a. Why? b. What conditions are necessary to form 1,1'-diacetylferrocene as the main product? c. Why does 1,3-diacetylferrocene not form under these conditions? 2. During workup of the product, water reacts with the excess acetic anhydride to give what side product(s)?
3. Rank the reactivity of the compounds shown below when using a Friedel Crafts alkylation reaction. Make sure you label which is least reactive and most reactive. (5 pts) 4. Provide a plausible mechanism for the reaction shown.(6 pts) =100
The following questions are from an experiment titled Friedel-Crafts Alkylation for Organic Chemistry II Lab. There are pictures attached of the lab manual. 2) Is this method a good route for the preparation of p-sec-butyltoulene? Give reasons for your answer. 3) Why do you use a large excess of toulene. What are its functions? 4) What is the purpose for adding the hydrochloric acid to the water in the separatory funnel in step 5? Hint: If no acid is added,...