Question

Based on the known function of talin, which of the following would you predict the outcome of genetically deleting talin in platelets, and why? Impaired ability to form blood clots because talin is the key adaptor protein linking the platelet cadherins to the cytoskeleton Impaired ability to form blood clots because tain plays an important role in activating platelet integrins Spontaneous blood clot formation because talin binds to integrin cytoplasmic tails to prevent integrin activation Spontaneous blood clot formation because talin functions as a kinase, phosphorylating the cytoplasmic domain of the thrombin receptor and triggering its internalization

Answer 1

Sol. B is correct option.

Talin is an important factor required for clotting of blood. It does this by integrin-mediated platelet function.