Question

CASE F: A 71-year-old Chinese male was admitted with complaint of chronic cough and malaise for two months. He had been in Tucson, Arizona, USA, visiting for four months right before the sym sweats, skin rashes, or headache. His past medical history included four years of primary hypertension and three years of coronary heart disease. He did not smoke or abuse drugs. Physical examination revealed no abnormalities. Chest computed tomographic ptoms occurred. He had transient low-grade fever, but denied hemoptysis, night (CT) scan revealed an irregular-margined opacity measuring 3.0 cmx3.8 cm in diameter in the sub-pleura region of right middle lobe. Right hilar and mediastinal lymphadenopathy was noted Lung cancer was considered as the most likely diagnosis. Subsequen bronchoscopy and brush cytology were negative. The patient received a procedure of right middle lobe and lower lobectomy on the eighth day after admission Histopathological examination of the surgically obtained lung specimen revealed a solid mass of 5.0 cmx4.0 cmx1.5 cm in the right middle lobe. Microscopic examination showed foca I necrotic granulomatous inflammation with multinucleated giant cells containing tungal spherules and infiltrations of massive neutrophils, eosinophils, and lymphocytes Some other free and typical large, encapsulated spherules with endosporulation measuring 40 μm in diameter could be seen in the surrounding tissues PASM stains were all positive while the fast stain was negative.

Answer 1

OAs the data explainedl in the case, the pa-lient ,the patient is suffoning ro a fongal dlisease kno) coccidioides cohich is an infPection infec-lion als0 called as valley fever This fonju,s is present in endlemic aea cohere pa-lient visiled aJ Vall e This occux due to lhe piople affecled by mic so ople afFecte Scopic fongal spores lt is oral YOute paseo Iv ecal G-This osganism is dimosphic. And it have two species Cocidiodesơmitiš and c. Poçadasii This fongi exists in both yeast or mole for accordinq -lo envixonment conalitions. it exists as mold in environment andl ypherule In víVo, its equlate. oim oxphism is not -tempesatore Anti fongal age nts shich asie used to eat Coccidiooles ae Cas p ofungqin and/