Why does HIV preferentially infect cells that have CD4 receptors?

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Question

Answer 1

Answer #1

HIV infection leads to loss of CD4 T lymphocytes through their destruction.
In the persons affected with HIV, the CD4 T lymphocytes show more HIV specific memory compared to normal CD4 T cells in the uninfected persons.
Infected CD4 T lymphocytes become the reservoir of HIV viral DNA.
HIV specific CD4 T lymphocytes when they infected with HIV in vivo result in their loss/destruction of their specific activity.
Once the CD4 T cells get lost, the immunological suppression of HIV could not be controlled.
This shows the HIV suppressing therapy interruption through increased viral burden, killing of CD4 T cells and inability of CD4 T cells in inducing cytotoxic T cells in killing viral infected targets.

Answer 2

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