When an ATP synthase was inhibited by metabolic poision, it causes increase of H+ concentration in the mitochondrial membrane causes lowering of pH. Hence, the graphed line gradually decreases i.e pH gradually decreases with time
DRAW IT The graph here shows the pH difference across the inner mitochondrial membrane over time...
Inhibitors of Oxidative Phosphorylation The following chemicals inhibit oxidative phosphorylation: Cyanide: Cyanide is a naturally occurring compound that binds to protein complex IV of the mitochondrial electron transport chain and prevents transfer of electrons from the protein. Metformin: At the cellular level, chemically synthesized metformin, a drug commonly prescribed for Type 2 diabetes, inhibits mitochondrial respiration by blocking complex I. Dinitrophenol: Dinitrophenol is a metabolic poison that can be sold legally as a pesticide. Although it is lethal to humans,...