(a) (b) (c) (d) Predict the product(s) for the following reactions. Indicate the pathway (E1, E2,...
3. Predict the major product (only one product) in each of the following reactions and indicate the type of mechanism. 3. Predict the major product (only one product) in each of the following reactions and indicate the type of mechanism. (3 pts; no partial point) Mechanism Sn2 Sn1 HO HBr moy ng heo 0°C, H2O E2 E1 Mechanism Sn2 Sn1 H2SO4 E2 E1 Mechanism HBr SN2 Sn1 rt, H20 E2 E1 OH
For the following reaction, (a) predict the reaction pathway (SN2, E2, SN1/E1) based on our predictive model and (b) draw the product(s). ONa
1. Predict whether the following reactions are likely to proceed by an E1 or E2 mechanism. PLEASE show the mechanism and product of the reaction!!!! 2. Explain each prediction. Predicting mechanisms: E1 or E2? 1. Predict whether the following reactions are likely to proceed by an El or E2 mechanism. 2. Explain each prediction. Br co KOH H2O Br CH,CH,OH Br CH2CH OH CH,0/CH,OH Br
1. Determine whether the following reactions will go through SN1, SN2, E1, or E2 mechanism a. 1-bromobutane + sodium hydroxide b. 2-chloro-2-methylpentane + sodium hydroxide + heat C. 2,3-dimethyl-3-bromopentane + water d. 2-bromobutane + methanol 2. Draw the major product for the following reactions (draw both products if racemic): NaSH DMSO TsO CHA Nal CH, acetone CH,CH,ONa+ ethanol CH,OH/H-0 Solite Nal (1 equiv.) acetone F CH2CH OH 25°C
Predict the product of each reaction below and indicate if the mechanism is likely to be SN1, SN2, E1, E2, or E1cB. OH 0 a) T T + NaOH H2O ONa + CH3CH2I DME (d) X + CH3CH2ONA CH3CH2OH
4. Predict the products of the following reactions & indicate whether they are most likely to go through an SN2, SN1, E1, or E2 mechanism. NaCN DMSO NaOH CH3OH heat Only one product is formed in the following E2 elimination reaction. Draw an arrow-pushing mechanism for the reaction and provide the correct product structure. Include a 3-D drawing (chair conformation) displaying proper stereochemistry of the transition state to explain formation of only the major product. CH3 •Br NaOCH3 ~"'CHS
3. Predict the major product (only one product) in each of the following reactions and indicate the type of mechanism. (3 pts; no partial point) Mechanism SN2 Sn1 HO HBr 0°C, H20 E2 E1 Mechanism Sn2 Sn1 H2SO4 E2 E1 Mechanism HBr Sn2 Sn1 rt, H20 E2 E1
Draw the major product and label as SN2, SN1, E2, or E1 7. Draw the major products of the following reactions, and label the reaction as SN2, SN1, E2 E1. (Darkly shaded bonds are wedged) Br NaOMe NaCN H2SO4 OTs NaSH OTs H20 NaOMe Br KOtBu OH HBr HBr OH
Q1) provide the product for the following reactions, identify as Sn1,Sn2, E1 or E2. Also provide the mechanism of the reaction H20 Br NaCN DMSO b). Csi Меон сін C)- KOH ci H d)_ this reaction was run at 100°C and 0.1 M KOH concentration 2) Rank the members of the following groups in order of basicity, nucleophilicity, and leaving group ability. Expain your answers a) H20, OH, CH,CO2- b) Br", ".Fr 3) Predict the effect of the changes given...
For letters h & i : For each of the following reactions, predict the major mechanistic pathway (SN1/SN2/E1/E2) and the major organic products 1. (cont.) (h) НСОН CHB -CHBr HCOH - (0) CH,CH,CH,CH,Br- NH 2. For each of the following indicate which reaction will occur faster. Explain your reasoning. (No credit will be given for guesses) (a) The reaction of (CH),CBr with 0.001M aqueous NaOH or 0.10M aqueous NaOH (b) The reaction of 2-bromobutane with NaOH in DMSO or NaSH...