a)E2
b)SN2 and R
c) E2
d) SN1 and S
15. For each of the following processes, indicate which mechanism is preferred: Sx1, Sx2 or E2....
8. [18 pts) Provide the expected organic product(s) from each of the reactions below. Ignore the stereochemistry. No mechanism required! (3 points for each organic product, switching the major and minor will be penalized) a. Major: NaOCH; E2 Br b. Major Minor OH E2 Br 3 products in total CH,OH ΕΙ 6. 19 pts] For each of the following reactions, give the organic product(s), and include the stereochemistry when applicable. No mechanism required! (3 points for each organic product) a....
3. For each reaction, draw the structure of the major product(s) including stereochemistry where appropriate. Fill n the box below each arrow with the mechanism(s) that will be followed (SN1/E1, SN2, or E2). For SN1/E1 reactions, draw products for both. NaCN DMF tBuOH 言言言 MeOH * | CH30 CH OH DMSO R-2-bromopentane
2. Draw mechanism arrows to indicate all movements of electrons in each transformation below. VB + Con DME_, van. + BO SH + X, CHOH SH+ Y CHOH. Von CH3OH Yon til + Å O CHOH HyC- 3. Use the axes below to sketch an energy diagram for the second reaction above, where a thiol reacts with tert-butyl iodide. Free Energy, Gº Progress of Reaction 4. Draw the structure of the major product(s) expected from each reaction below. Indicate stereochemistry...
4. [12 pts] Propose mechanisms for the formation of all 3 products shown in the reaction below: (draw curved arrows, intermediates, and resonance structures if necessary. NO NEED FOR TRANSITION STATES! CH CH CH CH Br Heat CH,CH,OH OCH.CH Mechanism.14 points) Mechanism 2 points) Mechanism.3 14 points) 5. [14 pts] Provide the major products of reacting the alkene shown in the middle of the scheme below with all the reagents independently. Draw the products' structures in the corresponding table below...
Draw the structures of the product(s) of the six reactions below. Clearly indicate stereochemistry where needed. If a pair of enantiomers results, clearly depict both enantiomers. If you think that there will be no reaction then write: "No Reaction." Racemic Mixture Br2in CCI H2 and Pt H\OTs H3C (C) KCN in DMSO (s,2 Product) KOtBu and Heat in tBuOH CH3 OTs H,C OH 1Tsa in Pyridine 2) KOtBu and Heat in tBuOH CH3 CH CH 0% 2) Excess (CHJ2S Draw...
E2 Reaction 2. Draw all constitutional isomers formed in each E2 reaction and predict the major product using the Zaitsev rule. Be OH El Reaction 3. What alkene is the major product formed from each alkyl halide in an El reaction? 4. Label the mechanism as SN2, SN1, E2 or El. You do not have to draw the product(s). CHO CH3-C-CH2-CH CH
For each of the following reactions, determine which ELIMINATION mechanism (E1 or E2) will occur. Alkyl Halide Substitution: Methyl 1° 2° 3° Base Strength: Strong Weak Mechanism Type: E1 E2 Draw the mechanism that leads to ALL products for the reaction. Finally, underline the major product of the elimination reaction: H3C OH H2C H2C1 Br CHE
Your Turn Which Mechanism is it? 5. In each of the problems below, consider the E1 or E2 reaction occurs then show the mechanism and product or products. Label major and minor products where applicable. a. Reaction of 1,1-bromomethylcyclohexane and sodium ethoxide in ethanol CH, OH сн. b. Reaction of (1R 2R) 1-bromo-2-methylcyclohexane and sodium ethoxide in ethanol. HINT: You should draw the ring in a chair conformation first. CHE 90 -CH, CH,CH,OH C. Reaction of (15,2R) 1-bromo-2-methylcyclohexane and sodium...
6. Determine the mechanism of nucleophilic substitution for each reaction and indicate the stereochemistry of the products. (in WORDS - DON'T DRAW DRAW PRODUCT BUT NOT Stereochemistry A. Br Brt + CN-acetons B. Br or n + CH₃OH Hochz - + OCHCH DME> c. 7. Label each stereogenic center as Rors A. a c. HO B ...oh OH NH 8. How is each compound related to the first compound D-erythrose (A+B) Oh. HK CH OH 04 I CH -04 D-erythrose...
7. Indicate the most likely mechanism for each of the following reactions and give the expected major product (with stereochemistry as appropriate). нс-ОН. txi non o to * in -CI HH HCI CH, + N in