6. Determine the mechanism of nucleophilic substitution for each reaction and indicate the stereochemistry of the p...
1. Determine the mechanism of each nucleophilic substitution reaction and explain why? Draw the products including the stereochemistry. (6 points) Br + CN acetone d. ~ + CH,CO2H - Y Y + POCHE UCH DMSO + TOCH.CH DMF b. + B + OCH + CH4OH DMSO – w ! ho + OCHCH , CH,CH,OH DM . Br + CH3OH + CH3CH,OH
3. Determine the mechanism of nucleophilic substitution (SNI or SN2) for each reaction and draw the products. Be aware of stereochemistry. 8 + CN - dletone m et och cun, DE Br + OCH₂ CH₂ DME 4. Draw all constitutional isomers formed during each elimination reaction after determining whether it is E1 or E2. habel it as El or E2. госна. a y "ocha, B b. Tă CH₃OH Br -OH
1.) Determine the mechanism. (Sn1 or Sn2)
2.) Show step by step reaction mechanism of nucleophilic
substitution including transition states
3.) Draw the products, including stereochemistry
Br + CN acetone
Determine, based on the identity of the substrate, nucleophile, and solvent, the mechanism of nucleophilic substitution of each reaction and draw the products, including stereochemistry. OTS DMF y uns + ⓇCN MeCN 3) M Br + H3C-0-
ОН 8,49 Consider the nucleophilic substitution reaction shown here. Based on the stereochemistry, does it proceed by an Sp1 or SN2 mechanism? Explain. косна CH,OH + Enantiomer OCH,
I nucleophile substitution. 7.8 Which is the better leaving group in each pair? a a, b, NH, NH, C. HẠO, HAS 7.9 Which molecules contain good leaving groups? a. CH CH.CH,Br b . CH,CH,CH,OH . CH.CH,OH, d. CH.CH Does the equilibrium favor the reactants or products in each substitution reaction? a. CH,CH-NH, + Br -- CH,CHBr + NH b. n + ON ~ ON + r 7.6 Identify the nucleophile and leaving group and draw the products of each reaction...
3. Indicate the nucleophilic group and the electrophilic group in each of the following reactions, then draw curved arrows to show the electron flow: (a) H- N H -CH: (D) - (C) NH :CI: CI-APë: :CA: 1-ci: A-CI: 4. The following reaction has a small, positive AG and takes place slowly at room temperature: H3C-CI H-OH - H3C-OH - H-CI (a) The mechanism for the reaction is shown below. Which bond is being broken in the slowest step? Which bond...
(a) For each substitution reaction, circle whether it proceeds by an Sy1 or S 2 mechanism. (1.5 pts) (b) Draw the major organic product for each reaction. Be sure to indicate the appropriate stereochemistry, where necessary (1.5 pts) 2. NaCN S1 or S 2? Br THF SN1 or Sy2? но CH3 Hас, SN1 or SN2? CH,он
6.25 Listed below are several hypothetical nucleophilic
substitution reactions. None is synthetically useful because the
product indicated is not formed at an appreciable rate. In each
case provide an explanation for the failure of the reaction to take
place as indicated.
(Problems A, B, D, and E needed)
o. With methyl, ethyl, or cyclopentyl halides as your organic starting materials and using any needed solvents or earlier parts outline in syntheses of each of the following More than one step...
To Understand the Mechanism of No 1-Bromobutane Post lab questions rstand the Mechanism of Nucleophilic Substitution (S2) Reaction: Synthesis of swer the following questions in the discussion part of the lab report of Experiment 7 on Sn2 reaction. 1. What is the purpose of refluxing the reaction mixture for 45 min? Why not simply boil the mixture in an Erlenmeyer flask? 2. When X is heated with an equal amount of Y in an inert solvent, product Z forms by...