Question

I nucleophile substitution. 7.8 Which is the better leaving group in each pair? a a, b, NH, NH, C. HẠO, HAS 7.9 Which molecules contain good leaving groups? a. CH CH.CH,Br b . CH,CH,CH,OH . CH.CH,OH, d. CH.CH Does the equilibrium favor the reactants or products in each substitution reaction? a. CH,CH-NH, + Br -- CH,CHBr + NH b. n + ON ~ ON + r

Answer 1

Solutions - 7.8 @ I is better leaving group than ceo due to bigger size of to than cro so sodine form weaker bond than chlorine with carbon (considering hydrocarbon molecule) Todide is no weaker bare than co behet A by NH3 in more leaving group tham Whoo considering the conjugate acid of these two Ni in more acidic so its conjugate bace NH₃ is less basie so it in good leaving. Another reason of this is NH3 be a garo the leaving process in entropically favourable > His in leo barie Clewis base) than H2o HS is better leaving than Hoo. This is due to also the larger size of sthom o. H2 CH₂ CH2 Bor contain good leaving a group due to learger size weak barisity & capable of stabilizing are charge Br is good leaving group. > Ctz CHzotz Hot is a good leaving group due to the great electrone gativity of anggon it favowys negative ore at least neutral state, AS here Hool contain onygen in positive stode so H2ot is a leaving group.

7.107 city CH₂ CH₂ WHp & Bro CH CHi Br + H2 The rekh in not possible as it in very poor leaving group. Brb in lena barie than NHO so the reach does not take place 0 9 be & CN net 10 EN acts and good nucleophile It acts as good leaving group due too longer size of Iodine & capability of Stabilizing the negative charge The reaen equilibrium shifts to the right side. The reaon is posside. 7. & 88 CH₂ CH3 Here Bay in the leaving group & Here the elimination reach takes place due to the larger size of ethonide base беа дос- u + NaOH ao is the leaning OH > I n substitution Elimi nation. He is a strongly bare also nucleophile Here both elimination & substitution takes place

> ~ + Na m no No acts aro nucleophile f 1 an a good leaving group. substitution reach takes place N . az o BM + NaN - O Bro acts and pood leaving group & CNO as a good nucleophile. Substitution reaen takes place Substitution. 7. 777 Dort i N (H2 (43) Elimination t o ret alts) SN1 RKn b) (CH₂)₂ C-cl + Host stable Carbocation JH20448 (CH3)-erot (pdt) > B1 fort chén PCm C# ng cagay no ① CH₂OH/-HO I SNI Bro осом, (pat carro cation teaving gr