Question

Diagram the activation of the 5-HT Serotonin Receptor (G-Protein Coupled Receptor) leading to transcriptional activation in a neuron. Include signaling pathways you have learned about in lecture or in your reading that involve G- Protein Coupled Receptors and lead to gene activation. Demonstrate how Lithium acts to disrupt one of these signaling pathways. (20 points) 5.

Answer 1

* Sevotonin (5 - hydroxytryplamine,) 5. HT is a neurotransmitter that in multiple process, including autonomic function, motor activity, hormone secretion, cognition, and Complex processes associated with affection emotion, and reward1. 5HT receptors, or serotonin receptions are a group of G - protein. Coupled receptor and ligand - gated ion channels funds in the central and peripheral nervous systems. They mediate both excilatory and inhibitory neuro transmission. The serotonin receptors are activated the nuerotransmitter serolonin, which acts as their natural ligand. The secrotonin receptors influence various biological and neurological processes such as aggression, anxiety, appetute congnition Learning memory, mood nausea, sleep and there moregulation The serotonin receptors are the target of a variety of pharmaceutical and psychotics, and sevotonini receptor are turned in almost all animals and are even know to regulate longevity and behavioral going the primitive. The canonical model GPCR regulation posits that The ogonist bound receptors is regulated though interaction with B - arrestins. GPCRS are phosphorylated by GPCR kinases (GRK_c) thus