Question

Synthesize the following diketone. All carbons in the product must come originally from molecules of methanol.CH OH

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Answer #1

When Methanol is added to HI then Water gets removed and MeI is formed .

Before adding Mg, completely drying is needed and then Grignard reagent is formed.

In step-II , commercially available cyclic anhydride is made into such a molecule that we reach our min target.

Step-III, first acyl chloride is substituted as this is more electrophilic than ester and then use of LDA ensures the less substituted enolate and forms 6 member ring.

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