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Consider the following statement from the text, “Immunologists had to face the fact that there simply...

Consider the following statement from the text, “Immunologists had to face the fact that there simply was not enough DNA to encode all the relevant B-cell receptors, using the one-gene, one-polypeptide chain rule.” In one sentence, could you explain, in your own words, what this statement means to a fellow student in your immunology course?

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The fact that sufficient DNA is not present to represent the complete spectrum of B cell receptors would mean that a single gene is somehow able to code for multiple polypeptide chains which implies that the single gene is altered in some way to generate the large number of B-cell receptors found in the B-cell population.

This suggests a mechanism of either alternative splicing or genomic recombination, which would allow a single locus to generate a large number of variants.

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