How could spending 2 weeks at 18,000 ft put a person into negative nitrogen balance?
- 18000 ft is a very high altitude. At such high altitudes the
partial pressure of oxygen in the atmosphere is very low.
-This results in hypoxia.
- Also at high altitudes the appetite is affected resulting in
reduced hunger and desire to eat.
- At higher altitudes low oxygen availability results in higher
respiratory rate and increased load on cardiovascular system which
increases the metabolic activity of body cells. The body needs more
energy which is derived from carbohydrates and fats.
- But once the carbohydrates and fat stores deplete the body
switches to proteins stored in muscles for energy. This results in
reduced muscle mass.
- All these factors reduces the body weight.
- high altitudes also results in diuresis which cause loss of
nitrogen in urine.
- The above factors also results in imbalance between the nitrogen
intake and nitrogen loss.
- The nitrogen intake is reduced due to reduced appetite and desire
to eat. But the nitrogen loss through urine and mobilizing protein
stores for energy increases nitrogen loss.
- In such a scenario where nitrogen loss exceeds the nitrogen
intake results in negative nitrogen balance.
How could spending 2 weeks at 18,000 ft put a person into negative nitrogen balance?
Tell if the nitrogen balance would be positive or negative if the person takes 95 g of protein in a 24-hr period, and has a urinary urea nitrogen output of 11.6 mg/mL and a 24-hr urine volume of 1200 ml.
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