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4. Metabolic myopathies: There are many types of metabolic myopathies. Our laboratory is currently studying McArdles Disease, also called glycogen storage disease type V. A defect in which enzyme is associated with this disease? Why does this defective enzyme ultimately lead to renal failure in many cases? to
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There is deficiency of an enzyme called phosphorhylase or myophospho rhylase in skeletal myscle. So due to this there accumulation of myoglobin. This causes intratubular obstruction or tubular necrosis. And this leads to impairement of renal function causing renal failure in many cases.

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