Question

24.Consider a transcription regulatory protein that has both a nuclear localization and a nuclear export signal and is normally found both in the nucleus and in the cytosol at comparable concentrations. This protein has a high-affinity binding partner in the nucleus. Upon activation of a certain signaling pathway, the binding partner is ubiquitylated and degraded. As a result of this,... the transcription regulatory protein accumulates in the nucleus. the transcription regulatory protein accumulates in the cytosol. expression of its target genes may be altered. expression of its target genes is not necessarily changed as a result of the C. the distribution of the transcription regulatory protein does not change, but the D. the distribution of the transcription regulatory protein does not change, and the degradation event.

Answer 1

B. the transcription regulatory protein accumulates in the cytosol.

explanation; the post trancriptional modification of Ran- GAP1 proteins by Sumo-1 . Ran-GAP 1 is a GTPase activating protein for Ran which involve in the nuclearcytoplasmic transportation.