Question

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Given the structure and pK, of aripiprazole (Aricept), select the predominant form in the gastric juice (pH 1.0) , that will not allow passage of the drug into the mucosal cell eytoplasm, 4. according to the pH partition theory. pans pK, 7.48 ఇ Pan Option Option I Option I Option V Option IV A. Option I B. Option II C. Option II D. Option IV E. Option V

Answer 1

Structure of aripiprazole dimirable to . Þka = 7.48 Now art in the gastie juice (at pH= 1), brzo - Tone paire of N and o can abstract proton (H+) from the solution. Ami . Now we know that basicity of N is more than o as lone pair atsi availability on N is greater than o to donate. Oxygen (o) is more electronegative than a nituogen (N) is the main reason for this fact. and option & will not be So, option Ill answered,

ja tautomeris mijn Now between 1, 2 & 3 non-atom, 1 and 2 mis sp² hybridized and 3 no. is .. Sp2 hybridized. So the basicity of 1 and 2 no. N-atom is more than 3 ha. N-atom. As with increasing s-Character et Ny basieiry decreases. So, Option it is not answer ago ete

Now lone pain of 1 no, N is participate in resonance (treffect) with the benzene - derivative ring. So, the lone baube availability of 1 no, Nis less than 2 no. N. so the basing of a no. Ne more than a no N catom, So, option I is not answer and option II is the consueet ansurer, II. Predominant Product