Question

Home Assignment (1) Work on the following home assignment (1): 1. Write brief bulleted points summary on the development of pharmacopoeias starting from the US, UK, World, and Indian Pharmacopoeias. 2. How did the pharmacopoeia tell us about the development of drugs? For example, the first edition of a pharmacopoeia has info on Captopril, other on Lisinopril, next or other edition has info on Fosinopril, and so and so forth! Briefly elaborate on your answer! 3 What is the relationship between transmittance and absorbance? How a shift to higher absorbance is described, does it changes the intensity of absorption? 4. Give examples of two absorption spectroscopies examples. How IR is different than the UV/UV-VIS? 5. How the positions of carbonyl group absorptions change based on the functional groups? How the changes are followed for C.C single, double and triple bonds? (These questions are not intended for any tests, only an exercise to solve model questions)

Answer 1

1.
ha copoea was published ou 15th internals. ed at 10 year . From 1942 - 2000 There are many editan combination of two official Us Pharmacopoeia - • First edition of us Pharama capoeia ca December 1890 in both Latin & English . From les tom 1820 - 1942 it was publiched at 10 year at 5 year intern 142 - 2000 it was published o from 2009, it published annually. are many edilieu of USP-NFC Uwled Slale Pramacopote Nalloral formularion) For example The USP35- NF ao' is a combination of two of olependia: The 'us p' and 'NF and is oftreally applicable from may, 2012 to 30 April 2013. A UK pharmacopoeia de First edition was published in 1864. • It couslet of two sectious. Part I - Material medica Part II: Preparation & compounds, - lu BP 2007 monographe has been been introduced for material specifically used in preparation of traditional chinese medicines. o Bo 2008 contains approximately 3100 monographs for substances, preparation and articles weed in practice o indian pharmacopoeia- et offefal Pharmacopera of India appead in 1868 wwen was edited by Edward John waring. In fre Pudepence days, British Pharmacopeia was in India used sian Pharmacopeio commitee 1st edition of If in last . under Dr. B.N Choch publishd
3.

HJ The amount it radiatim absorbed may be measured in ano ot weegs. transion Homees, T=PPo. C/ Transmittance & 1 T = 100T. Absorbom se, a= logo Polpur se A = 109.. . A - 109,0 100/1 a = 62-logios. According to bear lombert's low. torm A-Ebe. 4o ( A = Absorbance E = motor absorptivity b= path length of sample. C= concenrretion at comp in solutions expreesed in moll! The change is absorbom ce in the higher side. is known as hypsochromic shift. Adi And if there is om increase in the absorptivity uticases it the spectrum to become more intense. it is knownes hyperchon.