The work of the debranching enzyme is to help in the breakdown of glycogen, which stores glucose in the body. Glycogen stores carbohydrate energy in the body.If there is no debranching enzyme it will lead to glycogen storage in liver and muscles. This can result in low blood sugar which is responsible for the loss on consciousness and overall weakness , can result in enlargement of the liver due to the deposition which may hinder its function and also muscle will have no strength.
In order to treat this the person is given high-protein diet to start gluconeogenesis and in rarest condition, a liver transplant is needed
What issues would happen if there were no debranching enzymes for glycogen?
Sort the following enzymes according to those required for glycogen synthesis and those required for glycogen breakdown. (Note: Not all enzymes may be used.) Items (7 items) (Drag and drop into the appropriate area below) UDP-glucose pyrophosphoryla Glycogen branching enzyme Pyruvate carboxylase Glycogen synthase Phosphoglycerat e kinase Glycogen debranching enzyme Glycogen phosphorylase se Categories Glycogen Synthesis Glycogen Breakdown Drag and drop here Drag and drop here
Which of these enzymes is correctly paired with one of its immediate products? a. Glycogen phosphorylase: Glucose 6-P b. Fatty acid synthase: Oleate c. HMG CoA Reductase: HMG CoA d. Debranching enzyme: Free glucose
If the cell had high [ATP] and low [AMP], what would you expect to happen to the following processes (i.e. process vs. not proceed)? What causes them to process/not proceed and be sure to address any enzymes involved. Glycolysis Gluconeogenesis Glycogen breakdown Glycogen synthesis
A patient was seen by a gastrointestinal specialist and diagnosed with a glycogen storage disease. A liver biopsy showed that the patient was producing very little glycogen, the molecules were relatively small, and they only had a(1,4) glycosidic linkages. Blood and liver glucose concentrations were within normal ranges. What enzyme is likely affected in this disease? a. glycogen synthase b. glycogen phosphorylate c. branching enzyme d. debranching enzyme e. hexokinase
If glucose levels in the blood were low, which of the following enzymes would be active? a. none of these b. Carnitine-Acyl transferase I c. Glycogen synthase d. Acetyl CoA carboxylase
11. What would happen in a liver cell if citrate levels were high? Tell me what pathways would increase and which would decrease. Mention at least three key regulatory enzymes that would be affected as a result of this increase in acetyl-CoA. (10 pts)
3. What would happen to a cell if its lysosomes ruptured, allowing lysosomal enzymes to leak out into the cytosol? (10 points) ANSWER:
9. State briefly, us ing appropriate equations and enzymes, what would happen to Glucose-6-phosphate in a rapidly dividing cell where more ribose-5-phosphate than NADPH is required. (10 pts)
9. State briefly, us ing appropriate equations and enzymes, what would happen to Glucose-6-phosphate in a rapidly dividing cell where more ribose-5-phosphate than NADPH is required. (10 pts)
whats the effect of phosphorylation on the activity of the following enzymes? 1. glycogen phosphorylase 2. glycogen synthase 3. acetyl CoA carboxylase
Biochemistry help 1) Write the names of the degradative and the biosynthetic enzymes of glycogen metabolism that are targeted to regulate glycogen metabolism. 2) ) Discuss, by drawing structures, how hormones regulate the enzymes you name in Question 1. 3) Discuss, with structures, the reactions of the non-oxidative phase of the pentose phosphate pathway and show how the non-oxidative phase is used to synthesize all the pentoses in nature.