How many ATP equivalents are required to produce one molecule of urea from ammonia and aspartate?

Question

Question

How many ATP equivalents are required to produce one molecule of urea from ammonia and aspartate?

Answer 1

Answer #1

3 ATP equivalents are required to produce one molecule of urea from ammonia and aspartate.

NH₄⁺ ions to Carbamoyl phosphate - utilisation of 2ATP. Citrulline to arginosuccintae - breakdown of 1 ATP to AMP + PPi.

2NH₄⁺ + HCO₃^– + H₂O + 3ATP + Aspartate → Urea + 2ADP + 4Pi + AMP + 2H⁺ + Fumarate

Answer 2

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