Question

Patients with mutations in the genes encoding pattern recognition receptors (PRRs) are often particularly susceptible to certain types of infectious diseases. Predict which types of infectious agents will most strongly affect individuals with the following genetic defects by completing the table below. Use the following symbols for your predictions. You may place more than one symbol in a box if you believe it is appropriate!

B = Bacteria

F = Fungi

P = Eukaryotic parasite V = Virus

Pattern recognition receptor that is deficient: | TLR4 TLR L TLR12 | TLR3 RIG-I I Susceptible to:

Answer 1

The following table represents the answer based on the ligand binding on these receptors. Different pathogens have different ligands. Some of these receptors bind with DNA, RNA or Lipopolysaccharides, based on their property.

	TLR3	TLR4	TLR7	TLR12	RIG-I
Susceptibility	V	B,V,F	V	P,B	V