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2) Consider two loci that contribute to blood grouping, the first with alleles M and N, and the second with alleles S and s. In a sample of 1000 people from Ireland, the following frequencies were observed: MN blood group: freq(M 0.5425; freq(N) 0.4575 Ss blood group: freq(S) 0.3080; freq(s)-y 0.6920 a) What are the expected frequencies of all possible gametes assuming gametic equilibrium? Calculate the gametic disequilibrium D and D. Explain, in one sentence, what does the value of D b) In a separate population of 1000 people from England, the gamete frequencies below were observed. means. gMs 0.2370 gMs 0.3055 gNS 0.0710 gNs 0.3865

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clAssmate PM-p 0 5425 PMs = 1:0.5425×0-3010...- 0.16귀 3080 0.14 og 00 3166 NS 0.0710 NS /-D = 0.0699 = 0.4961. 0.1409 D max

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