While you work at a nucleic-acids focused biotech company, your best friend works at a small-molecule focused biotech company. Your friend’s company has developed a new small molecule that is bacteriostatic, and functions by preventing the action of Rho. How does this small molecule impact replication/transcription/translation in the bacteria that are treated with this compound and what is the expected outcome?
You first need to understand what role does rho plays in bacteria. Let us first understand what rho is-Rho factor is a protein and DNA contains the binding site for this protein. Rho factor binds to this sequence and starts "climbing" up the transcript towards RNA polymerase. When it catches up with the polymerase at the transcription bubble, Rho pulls the RNA transcript and the template DNA strand apart, releasing the RNA molecule and ending transcription. Thus Rho is used as a transcription terminator protein.
Now if any small molecule has developed in the biotech company which prevents the action of rho, then it means this molecule will prevent termination of transcription. This means an unwanted longer RNA will form in these bacteria which will eventually result in the formation of a longer protein with more amino acids than intended. Thus by altering the length of the protein, this molecule will disturb the overall metabolism in bacteria and thus stop them growing or act as a bacteriostatic molecule.
While you work at a nucleic-acids focused biotech company, your best friend works at a small-molecule...
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