Question

1 Kidney - two compartment model Stream 5 exit tubules to renal vein Stream 1- blood in Stream 3 exit glomerulus to renal vein volumetric flow ml min-1 ml min-1 mg ml-1 mg min-1 vol fract 5 volumetric flow mass flow RBC water protein mg min-1 vol fract 1200 ml min-1 volumetric flow mg ml-1 0.45 vol fract mg ml-1 mg ml-1 mg min-1 mg min-1 mg min-1 mg min-1 mg min-1 mg min-1 ens 7 mass flow 8 RBC 9 water 10 protein mg min-1 mass flow mg min-1 mg min-1water mg min-1 mg min-1 mg min-1 mg min-1 mg min-1 mg min-1 mg min- mg ml-1 mg ml-1 mg ml-1 mg ml-1 protein sodium urea 12 sodium 13 urea sodium mg min- urea Given 15 Stream 2 - filtrate Stream 4 - urine urine flow rate blood in flow rate filtrate flow rate RBC volume fraction in blood urine density blood density plasma density RBC densi blood plasma glucose blood plasma sodiunm blood plasma protein urine urea urine sodium urea conc ratio urine:filtrate no RBC or protein in filtrate no glucose in urine glucose, sodium, urea equilibrated between streams 1,2,3 1 ml min-1 1200 ml min-1 125 ml min-1 volumetric flow 1 ml min-1 mg m- mg min-1 vol fract 17 volumetric flow 125 ml min-1 0.45 1.026 g ml-1 1.056 g ml-1 1.024 g ml-1 1.098 g ml-1 mg m- mg min-1 vol fract ens mass flow RBC water protein glucose sodium urea 19 mass flow 20 RBC 21 water mg min-1 mg min-1 mg min-1 mg min-1 mg min-1 mg min-1 mg ml- mg ml-1 mg ml- mg ml-1 mg min-1 mg min-1 mg min-1 mg min-1 mg min-1 mg min-1 mg ml- mg ml-1 ucose 24 sodium 25 urea 26 1400 mg l-1 70000 mg l-1 mg ml-1 20,800 mg l-1 2500 mg l-1 29

Answer 1

Stream (1) blood in Volumetric flow - 1200 ml/min Density - 1.056 gm/ml mass flow - 1267 gm/min RBC - 0.45 vol fraction water - 55% protein - 70,000 mg/lt Glucose - 800 mg/lt Sodium - 1400 mg/lt urea - 20,800 mg/lt Stream (2) Filtrate Volumetric flow - 125 ml/min Desity - mass flow - RBC -Nill Water - 90% Protein - Nill Glucose - 200 mg/lt Sodium - 1200 mg/lt urea = 297 mg/lt Stream (3) (Glomerulas to Renal vein) Volumetric flow - 1200 - 125 = 1075 ml/min Density - mass flow - RBC - 0.45 vol fract water - 50% protein - 70,000 mg/lt Glucose - 600 mg/lt Sodium - 200 mg/lt urea - 20503 mg/lt Stream (4) urine Volumetric flow - 1 ml/min Density - 1.026 gram/ml mass flow - 1.026 gm/min RBC - Nill Water - 95% Protein - Nill Glucose - Nill Sodium - 2500 mg/lt