Question

Place the following mutations, all within the same codon in the open reading frame of a gene, in order from MOST likely to LEAST likely to eliminate the function of the encoded protein.

A. A transition mutation in the second position of the codon.

B. A transversion mutation in the third position of the codon.

C. A transition mutation in the third position of the codon.

D. A deletion of one base from the third position of the codon

Be sure to explain how and why you ordered them the way you did. Define any key terms along the way and provide diagrams to simply your explanations if necessary. There should explanation for all the mutations as you order them

Answer 1

Ans. The Correct order from Most Cikely to Least likely to eliminate the function of the encoded Protein is following - > A deletion of one base from the third position of the Codon (D) A transition suertation in the second position of the codon (A) of one A transversion mutation A transition mutation in the third position of in the third position the codon of the Colon (B) le ) Explanation for obtion - D. y Deletion base third position callse frame shift mutation, it meens forther colon from that base most likely change then their bence. amino acid change in brotein which change the function of brotein. s' - AUG C GG AUĄC 3' In RNA) & After translation Met Arg - lle most likely without mutation Deletion of 3rd base in first codon 5'- AUC GCA VAG-3? Laft After translation lleu Ala Pyr Prom this diagram we can understand whole AA Change in chain hence it will change protein function alto,

Ans. The Correct order from Most Cikely to Least likely to eliminate the function of the encoded Protein is following - > A deletion of one base from the third position of the Codon (D) A transition suertation in the second position of the codon (A) of one A transversion mutation A transition mutation in the third position of in the third position the codon of the Colon (B) le ) Explanation for obtion - D. y Deletion base third position callse frame shift mutation, it meens forther colon from that base most likely change then their bence. amino acid change in brotein which change the function of brotein. s' - AUG C GG AUĄC 3' In RNA) & After translation Met Arg - lle most likely without mutation Deletion of 3rd base in first codon 5'- AUC GCA VAG-3? Laft After translation lleu Ala Pyr Prom this diagram we can understand whole AA Change in chain hence it will change protein function alto,

One Explenation for obtion A À transition mutation in the second position also Cause changing in AA but this is the example of boint mutation here only change change in Amino Acid & Hence protein function chance but less chance then Delefon mutations s - Avey CGC AUAC -?' s'- Agg COCAUACal 2 - Met Arg - lley. Tyr - Asgalle without Mutation Mutation at zal position of first codon. for option B and @ genetic Coole, Ale- occur y 3rd position of codon is called wobble position (most cases) in to wobble Hybothesis y wobble position means useless that is if change in third base but amino Acid not change it is Same than (like) earlier called wobble loosition in whole genetic code it is Seen that one purina is wobble position to other one by simidine to other by simidine mees if third base of codon is burine in two colon then lees likely change in Amino Acid ,same with byrimidine y in baniition natation busine replace the other ose one bgrimidine replece other by simidine hence less chance to change th amino acid then from seversion because in transversion Purine replace with Lynnidine Vice - versa Herice protein function change least likely in transition in 3rd base than Gunverstion at third bace in mutation. vue > Phenylalanine 3'9f transition occur at thised both → Phenyl alene. UWA Leucine. } Transversion at thing the cause change cate one 06 vun AA will be same. Southern

One Explenation for obtion A À transition mutation in the second position also Cause changing in AA but this is the example of boint mutation here only change change in Amino Acid & Hence protein function chance but less chance then Delefon mutations s - Avey CGC AUAC -?' s'- Agg COCAUACal 2 - Met Arg - lley. Tyr - Asgalle without Mutation Mutation at zal position of first codon. for option B and @ genetic Coole, Ale- occur y 3rd position of codon is called wobble position (most cases) in to wobble Hybothesis y wobble position means useless that is if change in third base but amino Acid not change it is Same than (like) earlier called wobble loosition in whole genetic code it is Seen that one purina is wobble position to other one by simidine to other by simidine mees if third base of codon is burine in two colon then lees likely change in Amino Acid ,same with byrimidine y in baniition natation busine replace the other ose one bgrimidine replece other by simidine hence less chance to change th amino acid then from seversion because in transversion Purine replace with Lynnidine Vice - versa Herice protein function change least likely in transition in 3rd base than Gunverstion at third bace in mutation. vue > Phenylalanine 3'9f transition occur at thised both → Phenyl alene. UWA Leucine. } Transversion at thing the cause change cate one 06 vun AA will be same. Southern