Question

1. a. Assume that ∆G°’of hypothetical reaction A+B <--> C is 11.38 kJ/mol. At equilibrium, what would be the concentration of A and B if the concentration of C = 1mM?

b. In the hypothetical reaction, S<-->X⁺⁺ -->P (where S is substrate, P is product, and X⁺⁺ is transition state), rank the three molecules in descending order of free energy.

i. If the reaction is exergonic

ii. If the reaction is endergonic

Answer 1

In exergonic reaction the free energy is released thus, Gibbs free energy is negative during constant pressure and temperature. It can be denoted as

△G= Gproduct – Greactants < 0

The reactants also include the transition state.

Thus we can conclude that free energy of reactants is more than product.

Free energy of S > X++ > P

In endergonic reaction the energy is required thus; Gibbs free energy is positive during constant pressure and temperature. It can be denoted as

△G= Gproduct – Greactants > 0

The reactants also include the transition state.

Thus we can conclude that free energy of reactants is less than product.

Free energy of P > X++ > S