Question

Cells use signaling pathways to regulate processes that promote or inhibit growth/proliferation. For each scenario, decide whether cell growth/proliferation would be promoted or inhibited.

1) AMPK is inactivated:

2) Rheb is in its GTP-bound state:

3) Akt phoshporylates the TSC complex:

4) p53 drives the expression of p21;

5) pRB gets phosphorylated:

6) Adenylate kinase generates AMP:

7) Enhanced insulin/IGF1 signaling:

8) Telomere attrition:

Each option only choose either ""Promote"" or ""Inhibit""

Answer 1

1. AMPK is inactivated - Promote

2. Rheb is in its GTP-bound state - Promote

3. Akt phosphorylates the TSC complex - Inhibit

4. p53 drives the expression of p21 - Inhibit

5. pRB gets phosphorylated - Promote

6.Adenylate kinase generates AMP - Promote

7. Enhanced insulin/IGF1 signaling - Promote

8. Telomere attrition - Inhibit