Question

(26 points) Kineties of an Antiviral Drug. In 2016, Nature reported the discovery of a small molecule (GS-5734) that exhibited antiviral activity against the Ebola virus in rhesus monkeys (Nature, 2016, 331.381-385). That drug, now called remdesivir, is drawing renewed attention as a possible treatment for COVID-19. In the original study, the drug was administered by intravenous injection, 10 mg of GS-5734 per kg body weight of the rhesus monkey. A. (6 points) What's the typical body weight of a rhesus monkey? Cite your source for the above answer: So, in this study, how much GS-5734 (in mg) would they have injected into that monkey? B. (4 points) The study established a short half-life (tua -0.39 hr) for the elimination of GS-5734 from the blood stream. Assuming first-order kinetics, determine the rate constant for elimination of GS-5734 from the blood plasma in rhesus monkeys. Show your work and be sure to include the correct units in your answer. C. (14 points) One subject in the study received an initial GS-5734 dose of 68 mg 1. Assume the minimum effective amount of GS-5734 was known to be 41 mg. How long would it take for the GS-5734 in the subject's blood plasma to drop from 68 mg to 41 mg? Show your work

Answer 1

A) Female rhesus 5.3 ka male Rhesus 7.7 kg Source - Wikipedia since 10mg per kg In female 5.3x10 = 53mg male 7.7x10 = 870 me B) for first order k=0.693 ron -0.693 - 0.01776 hous' 0.39hr c) kt = ln ao t=1 lin 68 - 56.3x0.5056=28.46 hr 0.01776 41