Question

(25 points) Kinetics and Mechanism of a New Drug Candidate, then a Look Back at Part I. It is likely that remdesivir (GS-5734 in the last problem) will not turn out to be effective against COVID-19. Very few drugs in trial studies make it through to therapeutic use. Perhaps another research group will find a "natural product that is effective against COVID-19. Natural products are biological molecules that are often synthetic targets of organic chemists. Ifa natural product is found to treat COVID-19, someone will need to find a way to synthesize large abouts of the compound... and find it fast! Besides saving the world, that person will become obscenely wealthy. That person is... you. Because your work is propritary, you use labels instead of chemical formulas. Your one-step (show off) synthesis of the drug. D, found to be effective against COVID-19 is represented by the chemical equation shown below. A + B D + F Exp All reactants and products are in solution. A kinetic study of the reaction yielded the data shown below. [A] (M) [B] (M) rate (Mis) 0.15 0.15 4.3 x 10 0.15 0.60 17.2 x 10 0.45 0.15 38.7 x 10 A. Determine the experimental rate law for the reaction. B. Determine the rate constant, and be sure to include units. C. What would be the rate of the reaction when [A] -0.35 M and [B] -0.25 M? D. Consider this question before answering: If you increased the temperature, would the rate of the reaction increase, decrease, or stay the same? If you can answer the question, write down your answer and explain your reasoning If you cannot answer, what else do you need to know, and why do you need to know it?

Answer 1

CA] (in My 0.15 Collin M) a15 rate (m/s) 4.38105 Oobo 17, 2X105 oolr کسی/۲ 3 - 32 [ 0:15 3 0.45 rate law, ro R[A]" [B3% 1 x and y are apparent reaction order of reactant A and B respectively rate constant

Order wrot reactant À, keeps [3] Umstands Divide enferiment ② by O. - r , k l. H Lois) x 27 3 . x 4,3 xiss * 322 9232 order wirt reactants B, keeping [A] constant Divide experiment ② by 0, ICEF.)". 12.2010" - 4 17,2016t. 4.3 77-y = 4 q o y to rate tow; rok [A]²[B]'. By thing experiment No. 6, en 4,8x1053 k. x [0.153² (0.15] k = 1274.8748105 ko 1.274 8152 l² si i mole? C ra k[ 0:35] ² [025]" 1.2748102 M² 18012748 15 2X (0.35)2X10, 21) z 3:902 8104 M/s

22 Atce DPE (sleno) B ke , f fasts slowent step of the complese rate law is defined from the reaction mechanism, rokz [A] [c]' from fasts equalibrium Help, Keq = Rp 2 [C] k [1] [3] The CAD Ca][c] so, rakika [43€.com [rare CA2 (63) Reconetical rate laws) E If enperimental rate law law is known is known these and then we can say thats I the defined rate land matches with match or doesn't match with - the theoretical sate law.