Question

Hydroxychloroquine is one of several drugs being tested by the FDA as a possible treatment for COVID-19. Hydroxychloroquine is used for malaria and rheumatoid arthritis with two mechanisms. One is it blocks the virus. And the second is it tempers down inflammation, both of which play a role probably in how it's benefiting patients with COVID-19.(Dr. Agus) The drug molecule structure is given below. There are three different types of nitrogen in the molecule labeled as 1,2,3. Questions: 1) Based on the given molecule and lewis structure octet rule, draw the electron lone pair for each nitrogen. 2) Indicate the steric number for each nitrogen. 3) Draw dipole moments for all bonds formed around nitrogen. (label all three nitrogen)

Answer 1

The lone pair and dipole moment of each bond of nitrogen is shown by red colour.

HTT

• Nitrogen-1 has 2 bonds and 1 lone pair so steric number = 2+1 = 3
• Nitrogen-2 has 3 bonds and 1 lone pair so steric number = 3+1 = 4
• Nitrogen-3 has 3 bonds and 1 lone pair so steric number = 4

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