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4. (6 pts) Hemoglobin (Hb) binds to both oxygen and carbon monoxide. When the carbon monoxide...
Carbon monoxide (CO) is toxic because it binds more strongly to the iron in hemoglobin (Hb) than does oxygen (O2), as indicated by these approximate standard free-energy changes in blood: Hb+O2=HbO2 Delta G= -70 kJ/mol Hb+CO=HbCO Delta G= -80 kJ/mol Part A Estimate the equilibrium constant K at 298 K for the equilibrium HbO2+CO==HbCO+O_2
Carbon monoxide (CO) is toxic because it binds more strongly to the iron in hemoglobin (Hb) than does oxygen (O2), as indicated by these approximate standard free-energy changes in blood: reaction A:reaction B:Hb+O2Hb+CO⟶⟶HbO2,HbCO, ΔG∘=−70 kJ/mol ΔG∘=−80 kJ/mol Part A Estimate the equilibrium constant K at 298 K for the equilibrium HbO2+CO⇌HbCO+O2
The binding of oxygen to hemoglobin in the blood involves the equilibrium reaction: Carbon monoxide replaces oxygen in oxygenated hemoglobin according to the reaction: HbO2(aq) + CO(aq)HbCO(aq) + O2(aq) a. If the normal pH of blood is controlled within a range of 7.35 to 7.45. If the pKw is 13.63, what is the normal range of [H+] and [OH- b. What would happen if oxygenated hemoglobin became too acidic? c. Use the reaction and associated equilibrium constants at body temperature...
For the following questions consider this equation for hemoglobin – oxygen equilibrium. Hb + 4O2⥤ Hb(O2)4 Carbon Monoxide (CO) bonds to hemoglobin approximately 230 times stronger than oxygen. How would you increase the bonding oxygen to a patient with carbon monoxide poisoning?
1. Carbon monoxide poisoning can happen because carbon monoxide has a higher affinity for hemoglobin than oxygen does. This can be seen by comparing the equilibrium constants for the two reactions Hb(a)+02()Hb02(aq) Hb(a)C(e) HbCO(aq) K 1.9x1012 K 1.1x1014 where Hb is hemoglobin. The actual reactions are more complicated since each hemoglobin can accept up to four oxygen molecules, but we will simplify it for this problem A concentration of about 12,500 parts per million of CO is considered highly lethal....
4. The rate of the reaction between hemoglobin (Hb) and carbon monoxide (CO) was studied at 20°C. The following data were collected with all concentration units in umol/L. Note that a hemoglobin concentration of 2.21 umol/L is equal to 2.21 x 10 mol/L. Initial Hb Concentration Initial CO Concentration Initial Rate (umol/L) (umol/L) (umol/L-s) 2.21 1.00 0.619 1.24 4.42 3.00 3.71 3.36 2.40 4.42 100 a. Determine the order of the reaction with respect to hemoglobin and carbon monoxide. b....
Carbon monoxide binds to the active site of hemoglobin and inhibits the binding of oxygen. This is an example of _________________________. a competitive inhibitor denaturation a noncompetitive inhibitor an environmental inhibitor Scaffolding proteins can hold together can permanently hold together signalling pathways. True False
5) The rate of reaction of hemoglobin (Hb) with carbon monoxide was studies at 20°C. The following data was collected, with all concentrations in units of 10-6 mol/L. a) Calculate the rate equation, including the value of the rate constant, from the data shown. (20 pts) [Hb). 2.21 4.42 4.42 (CO). 1.00 1.00 3.00 Initial Rate 0.619 1.24 3.71 b) What would be the rate for an experiment where the initial (HB) = 3.36 x 106 and (CO). = 2.40...
9. Carbon monoxide (CO) is toxic because it can displace oxygen (O2) from the iron in hemoglobin (Hgb) following the reaction: HgbO2 (s) + CO(g) + Hgbco (s) + O2 (g) AG®rx = -30. kl/mol A. Consider the following reactions involving hemoglobin, O2 and Co: Hgboz (s) + Hgb (s) + O2 (g) AG®rxn = 40. kJ/mol HgbCO (s) -- Hgb (s) + CO (6) AGºrx = ??? Using Hess's law, determine the free energy AG*rn (in kJ/mol) for the...
104 Homework 6 4. (15 points): Hemoglobin (Hb) is the main oxygen transport protein in the blood. Each hemoglobin molecule can transport four oxygen atoms at a time, one at each of its four iron-based binding sites. The binding of O2 to hemoglobin is a pH-dependent equilibrium, simplified as: Use Le Chatelier's Principle to answer the following questions: a) What form of hemoglobin, HbH" or Hb(Ojle, would be favored in the lungs? What form would be favored in the cells...