Question

suggest 2 different synthesis methods

Synthesize any c8 acyclic or less

Using the starting material on the left, synthesize the product on the right. you can only use the starting material and any acyclic compounds with less than 8 carbons

Answer 1

Two synthetic schemes (Sceme 1 and 2) have been proposed for the target compound, the details are discussed as below.

The starting material used below is diethyl malonate instead of dimethyl malonate, which may not be so critical to achieve the target compound as required. I apologize for the same.

PAGE NO: DATE: Synthesis scheme e I og 9. Kotle, THE 85c o 2.20%. Naon, the go C, o 3.6Nnd 90°c Naost, etost (2 egun) 850 11. LA AMP I Target Diethyl malonate and XB- unsaturated ketone reacted following the three steps as below in Nucleshitic attack a malonate casbansan Korbu, Tut 8500 2. Hydrolyses of Beta keto ester (20%. Nust 201986) 3. Decarboxylation (GN.nl Heat this compound A is obtained - Next steps alkylation using above sheron alkyl halide resulted target compted

synthesis scheme 2 e Naosdisques) Etol I reflux . . Cas No - 187546-47-0 rolysis LiOH (1 equiv) 2. Decarboxylation THERE TON, 4 d , goc I Kotbu, Th., 850 I cylization LDA UMPA I Target Scheme 2. Alkylation a Diethyl malonate using I commerciallo avutable reagert resulted 4. etwas then hydrolysed using Leon (consol hyolysis) & decash oxylated to give ③. The cyclization A B with & B- unsaturated Ketone gave C. The allkylation of c resulted the target comporio