Drug A has an ED50
of 5.1 mg and an
LD50
of 49.9 mg, while
Drug B has an ED50 of 3.5 mg and an
LD50 of 36.1 mg. Determine
the therapeutic index (TI) for each drug. Which is safer? Why?
(There is no graph or image for this question)
Homework Answers
The therapeutic index (TI)of a drug is the ratio of the lethal dose (LD) to the effective dose (ED). High TI means safer the drug is.
TI = (LD50) / (ED50)
For drug A,
TIA = 49.9 / 5.1 = 9.8
For drug B,
TIB = 36.1 / 3.5 = 10.3
Drug B is more safer. It means in case of B it causes less toxic effect and more therapeutic effect compare to drug A.
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