Question

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-Briefly explain the roles of Salicylic acid, Acetic anhydride and phosphoric acid in the Aspirin synthesis reaction.

-What type of reaction is preparation of Aspirin?

-Briefly describe esterification and give an example using Acyl chloride as one of the reactants.

Answer 1

Date Page Acetic Anhydride An acetic acetylating agent some times aret acyl chlonde is also used but as it leads to formation a Hul, it is avoidable , so we use aletic anhydride. Use of Phosphoric Acid The acetylation process is very slow cat room or in absence of any and strong mid) The afet reaction goes very well with the presence of small catalytic amount Lot any strong and particularly Phosphine And, H₂ joy is also used as it is a good dehydrating agent . Acet foot the synthesis example of Both of asplan can be Esterification. It is a procees in which an - organic acid (tcoun) and alcohol CROH) reach to form and aster (RCOOR) and water, OR A chemical reaction which leads to formation of ester group in the synthesis is called esterification * The above of Buth a well, mentioned Acetylation (Aspirin 1 is a exampe and estentration

Date Page - Estearification low reversible and leads to formation of Hgo in product Cat room temp. and in absence 9 Aud) there fore, a small catalytic amount of strong and is used to for the reaction. Estenticchion is Both and -catalysed and Base - catalysed also using Example of esterification by acetyl chloride ch -(I + cha CH₂-04 Ethanol, Ayl chlonde CH₂-c-OCH CH + HUT