![1. [05 pts.] Draw the chemical equation for preparation of Aspirin. (No mechanism) 2. [15 pts.) Show the detailed mechanism m](http://img.homeworklib.com/questions/4cb5d4e0-d1d3-11eb-9755-df548c6f1942.png?x-oss-process=image/resize,w_560)
Homework Answers
3. The -OH group in salicylic acid make it nucleophile.
The carbonyl group of acetic anhydride provide the site for nucleophilic attack.
Phosphoric acid act as catalyst for this reaction.
4. The reaction of aspirin preparation is esterification reaction.
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1. [05 pts.] Draw the chemical equation for preparation of Aspirin. (No mechanism) 2. [15 pts.)...
can you explan these questions, I swear I will rate you! -Briefly explain the roles of...
can you explan these questions, I swear I will rate you! -Briefly explain the roles of Salicylic acid, Acetic anhydride and phosphoric acid in the Aspirin synthesis reaction. -What type of reaction is preparation of Aspirin? -Briefly describe esterification and give an example using Acyl chloride as one of the reactants.
1. [09 pts.] Draw the chemical equations for formation of hypochlorous acid and oxidation of cyclohexanol....
1. [09 pts.] Draw the chemical equations for formation of hypochlorous acid and oxidation of cyclohexanol. (No mechanism) 2. (11 pts.) Show the detailed mechanism for oxidation of cyclohexanol. Show all arrows to indicate movement of electrons. 3. [08 pts.] Briefly explain the roles of sodium hypochlorite and acetic acid in the oxidation of cyclohexanol.
H3PO4 OH + OH OH salicylic acid acetic anhydride acetic acid acetylsalicylic acid (aspirin) 1. Why...
H3PO4 OH + OH OH salicylic acid acetic anhydride acetic acid acetylsalicylic acid (aspirin) 1. Why is it better to perform acetylation with acetic anhydride rather than using a Fischer esterification with acetic acid? 2. Draw a complete arrow-pushing mechanism for the reaction. 3. When an old sample of aspirin is left in moist conditions, it will begin to smell like vinegar. Draw a reaction scheme and briefly explain what happened.
find the theoretical yield of the acetysalicylic acid . EXPERIMENT 19 PREPARATION OF ASPIRIN In addition...
find the theoretical yield of the acetysalicylic acid .
EXPERIMENT 19 PREPARATION OF ASPIRIN In addition to the Fischer esterification method presented in Experiment 18, a second method for preparation of esters involves the reaction of anhydrides with the hydroxyl This method is ospecialy usoful for tho preparation of acetate esters, since acetic anhydride is an inexpensive and reactive reagent. In this experiment the hydroxyl group of salicylic acid is acetic anhydride to make acetylsalicylic acid, or aspirin. The short...
Lab Section Nume Preparation and Examination of a Drug: Aspirin EXPERIMENT 25 OBSERVATIONS AND RESULTS 1....
Lab Section Nume Preparation and Examination of a Drug: Aspirin EXPERIMENT 25 OBSERVATIONS AND RESULTS 1. The Synthesis of Aspirin Record the weight of your aspirin, and calculate the percentage yield. Base the yield on salicylic acid since we acetic anhydride was used. Show all calculations. Weight of aspirin d. 08035 Yield of aspirin 2. Contaminants in Aspirin What was the color of the salicylic acid-ferric chloride test solution? On the basis of color is either your aspirin or commercial...
Organic chemistry -Carboxylic acid homework Question: In the general chemistry lab, students synthesize aspirin from salicylic...
Organic chemistry -Carboxylic acid homework
Question: In the general chemistry lab, students synthesize
aspirin from salicylic acid and acetic anhydride. In the lab,
students use sulfuric acid as a catalyst, but I want to consider an
alternate method for synthesizing aspirin using sodium acetate as a
catalyst:
a. Draw the structure of sodium acetate. Is sodium acetate a
stronger or weaker base than sodium hydroxide (NaOH). Explain. (1.5
pts)
b. Consider the structure of salicylic acid. It contains two
potentially...
please help me ! do you think this is good so far ? Results/Data • Aspirin...
please help me ! do you think this is good so far ?
Results/Data • Aspirin synthesis salicylic acid: 2.0 g Acetic anhydride: 2 mL d= 1.082g/mL sodium acetate: 0.4 g • Experimental yield of aspirin: 2.4 g FORMATION OF ESTERS II. PREPARATION OF ACETYL SALICYLIC ACID (ASPIRIN): 1 Complete the table below by entering appropriate values into the empty boxes. Show calculations for all entries clearly below. Reactants Chemical MW Grams of Moles of Moles of Limiting Melting Formula...
Experiment 11: Synthesis of Aspirin pre-lab (4 pts) 1) (2 pts) Refer to the introduction on...
Experiment 11: Synthesis of Aspirin pre-lab (4 pts) 1) (2 pts) Refer to the introduction on interpreting the ferric chloride test for phenols. Two students performed the aspirin synthesis experiment. Their melting point and ferric chloride test data are shown below. Based on the results, which student's aspirin has the higher purity? Justify your choice using the melting point data and ferric chloride test results. Melting point range for pure aspirin = 136-140 °C. Melting point range (°C) Ferric chloride...
Preparation of Aspirin Name Class & Section PRE-LABORATORY ASSIGNMENT 1. What hazards should you be aware of wh...
Preparation of Aspirin Name Class & Section PRE-LABORATORY ASSIGNMENT 1. What hazards should you be aware of when working with the following chemicals? a. Acetic anhydride b. Concentrated sulfuric acid 2. Explain the following terms as they relate to this experiment. a. Catalyst b. Limiting reactant 3. Following the procedure described in this experiment, a student reacted 2.775 g of salicylic acid with 4.0 ml of acetic anhydride and recovered 2.986 g of aspirin. a. Calculate the number of moles...
please help Mustrates treat all types of ilnesses. Background Aspirin is a prodrug of salicylic acid,...
please help
Mustrates treat all types of ilnesses. Background Aspirin is a prodrug of salicylic acid, the actual active drug. A compound related to salicylic acid, salicin, was first isolated from willow bark in the mid 1700's, but willow-bark extract was used by the andient Greeks as a treatment for pain and fever. Salicylic acid (and many related phenols) are very hard on your Ho stomach, but when esterified, as aspirin is, they are much better tolerated. Simple esters are...
1. [09 pts.] Draw the chemical equations for formation of hypochlorous acid and oxidation of cyclohexanol. (No mechanism) 2. (11 pts.) Show the detailed mechanism for oxidation of cyclohexanol. Show all arrows to indicate movement of electrons. 3. [08 pts.] Briefly explain the roles of sodium hypochlorite and acetic acid in the oxidation of cyclohexanol.
H3PO4 OH + OH OH salicylic acid acetic anhydride acetic acid acetylsalicylic acid (aspirin) 1. Why is it better to perform acetylation with acetic anhydride rather than using a Fischer esterification with acetic acid? 2. Draw a complete arrow-pushing mechanism for the reaction. 3. When an old sample of aspirin is left in moist conditions, it will begin to smell like vinegar. Draw a reaction scheme and briefly explain what happened.
find the theoretical yield of the acetysalicylic acid .
EXPERIMENT 19 PREPARATION OF ASPIRIN In addition to the Fischer esterification method presented in Experiment 18, a second method for preparation of esters involves the reaction of anhydrides with the hydroxyl This method is ospecialy usoful for tho preparation of acetate esters, since acetic anhydride is an inexpensive and reactive reagent. In this experiment the hydroxyl group of salicylic acid is acetic anhydride to make acetylsalicylic acid, or aspirin. The short...
Lab Section Nume Preparation and Examination of a Drug: Aspirin EXPERIMENT 25 OBSERVATIONS AND RESULTS 1. The Synthesis of Aspirin Record the weight of your aspirin, and calculate the percentage yield. Base the yield on salicylic acid since we acetic anhydride was used. Show all calculations. Weight of aspirin d. 08035 Yield of aspirin 2. Contaminants in Aspirin What was the color of the salicylic acid-ferric chloride test solution? On the basis of color is either your aspirin or commercial...
Organic chemistry -Carboxylic acid homework
Question: In the general chemistry lab, students synthesize
aspirin from salicylic acid and acetic anhydride. In the lab,
students use sulfuric acid as a catalyst, but I want to consider an
alternate method for synthesizing aspirin using sodium acetate as a
catalyst:
a. Draw the structure of sodium acetate. Is sodium acetate a
stronger or weaker base than sodium hydroxide (NaOH). Explain. (1.5
pts)
b. Consider the structure of salicylic acid. It contains two
potentially...
please help me ! do you think this is good so far ?
Results/Data • Aspirin synthesis salicylic acid: 2.0 g Acetic anhydride: 2 mL d= 1.082g/mL sodium acetate: 0.4 g • Experimental yield of aspirin: 2.4 g FORMATION OF ESTERS II. PREPARATION OF ACETYL SALICYLIC ACID (ASPIRIN): 1 Complete the table below by entering appropriate values into the empty boxes. Show calculations for all entries clearly below. Reactants Chemical MW Grams of Moles of Moles of Limiting Melting Formula...
Experiment 11: Synthesis of Aspirin pre-lab (4 pts) 1) (2 pts) Refer to the introduction on interpreting the ferric chloride test for phenols. Two students performed the aspirin synthesis experiment. Their melting point and ferric chloride test data are shown below. Based on the results, which student's aspirin has the higher purity? Justify your choice using the melting point data and ferric chloride test results. Melting point range for pure aspirin = 136-140 °C. Melting point range (°C) Ferric chloride...
Preparation of Aspirin Name Class & Section PRE-LABORATORY ASSIGNMENT 1. What hazards should you be aware of when working with the following chemicals? a. Acetic anhydride b. Concentrated sulfuric acid 2. Explain the following terms as they relate to this experiment. a. Catalyst b. Limiting reactant 3. Following the procedure described in this experiment, a student reacted 2.775 g of salicylic acid with 4.0 ml of acetic anhydride and recovered 2.986 g of aspirin. a. Calculate the number of moles...
please help
Mustrates treat all types of ilnesses. Background Aspirin is a prodrug of salicylic acid, the actual active drug. A compound related to salicylic acid, salicin, was first isolated from willow bark in the mid 1700's, but willow-bark extract was used by the andient Greeks as a treatment for pain and fever. Salicylic acid (and many related phenols) are very hard on your Ho stomach, but when esterified, as aspirin is, they are much better tolerated. Simple esters are...
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