write three different preparations of 1,1-diphenylethanol from three different carbonyl compounds and grignard reagents
III. Grignard Reagents. 1. (6 pts) Provide two different syntheses for 1,1-diphenyl-1-butanol starting from a carbonyl compound and using a Grignard reagent. Synthetic Route 1: carbonyl Grignard reagent a) THE b) H3O+ work up OH 1,1-diphenyl-1-butanol Synthetic Route 2: carbonyl Grignard reagent a) THE b) H3O+ work up 1,1-diphenyl-1-butanol
Please explain the mechanistic discussion of carbonyl group compounds regarding Grignard Reagents reacting benzophenone.
1. (6 pts) Provide two different syntheses for 1,1-diphenyl-1-butanol starting from a carbonyl compound and using a Grignard reagent. Synthetic Route 1: carbonyl Grignard reagent a) THE b) H30* work up 1,1-diphenyl-1-butanol Synthetic Route 2: carbonyl Grignard reagent a) THF b) H30* work up ОН 1.1-diphenyl-1-butanol 2. (3 pts) The use of Grignard reagents requires scrupulously dry aprotic solvents such as diethyl ether or tetrahydrofuran. Please explain why the solvents need to be scrupulously dry. To support your reason, show...
Give three different sets of reagents (a carbonyl compound and a Grignard reagent) that could be used to prepare the following compound. OH CH3-C-CH2CH3 CH3 Check all that apply Check all that apply. CH3 CH2 COCHg and CH3 MgBr CH, CH2 COCH3 and 2CH3 MgBr CH3 CH2 C CH3 and CH3 MgBr CH3 C CH3 and CH3CH, MgBr 0 CH3 C OCHZ and CH3CH, MgBr CH3CH, C CH3 and 2CH3 MgBr Submit Previous Answers Request Answer
II. What carbonyl compounds and Grignard reagents would you use to make the alcohols shown below? Show all possibilities. No mechanism necessary. (8 pts) НО. b OH
One of the most important uses for Grignard reagents is their addition to carbonyl compounds to give new carbon-carbon bonds. In this reaction, the carbon of the organometallic compound acts as a nucleophile to add to the positive carbon of the carbonyl forming an alkoxide ion intermediate. Aqueous acid is used in the second step to protonate the alkoxide ion and form the product alcohol. Draw the structure of the product(s) of step 1 when the following compound reacts with...
7. Retrosynthetic Analysis a. There are TWO different combinations of the Grignard reagent and carbonyl that can be used to make the product below. Think about TWO ways to make the product, listing the carbonyl and Grignard reagent in the designated boxes ОН Grignard Reagent Carbonyl or 2. Hао* Grignard Reagent Carbonyl b. There are THREE different combinations of the Grignard reagent and carbonyl that can be used to make the product. Please draw the three possible cominations of carbonyl...
7. Retrosynthetic Analysis: a. There are two different combinations of the Grignard reagent and carbonyl that can be used to make the product below. Think about TWO ways to make the product, listing the carbonyl and Grignard reagent in the designated boxes. Carbonyl on Grignard Reagent or 2H40 2. H.O Carbonyl Grignard Reagent b. There are THREE different combinations of the Grignard reagent and carbonyl that can be used to make the product. Please draw the three possible cominations of...
Organolithium compounds react with carbonyl compounds in a way that is similar to that of Grignard reactions. Draw the structure of the expected product when the compound below reacts with methyllithium followed by aqueous acid workup. organolithium compounds react with carbonyl compounds in a way that is similar to that of Grignard reactions Draw the structure of the expected product when the compound below reacts with methyllithium followed by aqueous acid workup. You do not have to consider stereochemistry. You...
Grignard reagents are used to make C-C new bonds. Their reaction with carbonyl compound leads to alcohols. However, when reacted with carboxylic acids carbonyl compounds are formed. Predict what should be the product of the reaction between 4-nitrobenzoic acid and phenyl magnesium bromide and explain in few chosen words why a carbonyl compound instead of an alcohol.