Question

Flavin-dependent oxidases and monooxygenases use O2 as a cosubstrate.

b) Starting from oxidized FAD, provide a complete curved-arrow mechanism to account for the transformation shown in part i. on the previous page (reproduced below). Include all flavin intermediates as well as the oxygen transfer step, and also be sure your mechanism accounts for the formation of all coproducts. CO2 NH3 H2018, O2 + NH® FAD

Answer 1

FAD = Flavin adenine dinucleotide (FAD) is brelly oxidized form, or quinone form, accepts two electrons and two protons to become FADHA. So, sit abstracts hydrogen fonc Proton). NHz → It is a better leaving group. © & NO HQ S01B FAD mechanism V Ning VERDD FROM Eco