Question

red suradienolides are described as cardiacglycosides owing to the similarity in their biological activity, the increase in the contractile force of the heart by inhibiting the enzyme Na+, K+-ATPase. Assign chirality (Ror S) to the asymmetric carbons present in the circled areas of the structure of Bufadienolide below? (choose the correct listed set of chirality in order from A, B, C, and D labels on the structure) 2.00 tion Select one: a S, R, RS b. S.RRR C. R, S, R, S f. R. S, SS

Answer 1

... solo According position, to CIP and rest rule, are Oy if the 4th priority is on dashed showing clockwise rotation then R - anticloakuise rotation then s wedge then reverse of above situation, If 4th priority is on

{ li first we assign - H is present on Rors dashed for ② marked. Carbon position, (i) secondly are assign for Carbom marked ® t It seems to be o but 4th priority is on wedge since it is I

lji) for B marked Carbon atom at seems ® but since 4th priority is on wedge a af is ®

Carbon mourked Gon prianity is on Wedge a. It looks to be R but actually it is ® option € S, R,R,S is correct.