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Which of the [4+2] cycloadditions would react fastest? © CHO + |||

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Answer #1

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For Diels-Alder reaction to take place the diene must assume the s-cis conformation. In 5-methylcyclopenta-1,3-diene, the diene is locked in an s-cis conformation within the rigid cyclic structure. Hence, the diene and dienophile in the first option would react fastest.

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