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Botulinus toxin causes paralysis by binding to presynaptic sites at the neuromuscular junction and prevents release of acetyl
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3.Botulinum toxin cannot cause any change to the membrane potential as it does not bind to emd palye potential but it can cause rearrangment of  presynaptic intermembrane particles induced by potassium stimulation.

4. Botulinus toxin on the end plate will cause a decrease in the threshold potential thus action potential cannot be attained and paralyses occur.

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