Question

4) In migrating cells, ______ are stable links between the ECM and the actin cytoskeleton

5) Which one of the following is true?

1. All integrin-containing adhesion complexes have the same cytoplasmic

   components

2. the spatial organization of integrin-containing adhesion complexes varies

   depending on the nature of ECM contacting the cell

3. integrin-containing adhesion complexes connect microtubules to the ECM

4. integrin activation involves conformational changes of the extracellular but not

   intracellular domains of integrins

14. What protective function does calcium gating serve in gap junctions?

Answer 1

4. Focal adhesion

These are the adhesion points by which a moving cell is attached to substratum .

5. option b is correct.

Integrin activates when its extracellular domain bind with a particular molecule and conformation change occurs in intracellular domain not of extracellular.

Integrin binds to actin which is a microfilament by help of proteins, not to microtubule.

All integrin containing adhesions doesn't have the same cytoplasmic components. There exists variety in the proteins as well as alpha and beta subunit of integrin.

Calcium helps in uncoupling the cell from its neighbour cells. This helps the cell from damaged neighbour cells. Increased calcium concentration inside cell leads to closing of gap junction .