1.The mechanism includes
action potential travels along presynaptic neuronintracellular calcium influxadherence od vesicles charged with acetyl choline to the presynaptic membraneSNARE proteinsvesicle exocytosisrelease of acetyl choline to the neuromuscular regionactivation of post synapsisopening of central ion channelinward flux of Na+muscle contraction.
when SNARE proteins are cleaved by protease it blocks the fusion of neuro transmitter containing vesicles to the plasma membrane and there by interuption of signal to muscles leads to muscle paralysis.
2.when the charges are reversed significant number of Na+ ions will move into the cell down their electrochemical gradient ,depolarizing the cell.
please answer me in no more than 7 sentences. thanks Please describe how the following changes...